Integra Nutritionals MunoGEN 250g

HKL-137:

• The cell wall of L.plantarum and other gram positive microbes contains a molecule called lipoteichoic acid (LTA). LTA activates the signalling pathways that regulate the integrity of tight junctions and the gut epithelial barrier, and readily binds to the Toll-like receptor, TLR2 on the surface of the gut epithelium¹.
• As a TLR2 agonist, HKL-137 is also anti-inflammatory and demonstrates anti-viral effects as a potent IFN-β inducer. Because it also has the ability to enhance production of Natural Killer cells, its known anti-viral effects extend well past its effect on bacteria, fungi and parasites.
• The Japanese research on HKL-137 has already demonstrated impressive immune modulation in several clinical trials³. Essentially, HKL-137 studies have shown benefits in reducing the frequency of colds and ‘flus, reduction of allergic responses, improvement in periodontal disease as well as in skin health, wound repair, quality of life and reduction in fatigue.
• Compared with other immune-enhancing probiotic organisms, HKL-137 was shown to exhibit superior immune-stimulating activity with a high safety profile².

Larch Arabinogalactans:

• The immune-stimulating polysaccharides from Larch Arabinogalactans provide nutrition for the microbiota, generating butyrate and other short-chain fatty acids that are the primary ‘fuel’ required by the colonocytes.
• Several clinical trials show that Larch Arabinogalactans at a dose of 4.5 grams daily demonstrate specific immune-enhancing properties in their own right. In one trial in humans, Larch Arabinogalactans were shown to decrease the incidence of cold episodes by 23%⁵; this was thought to be due to T cell-dependent mechanisms⁶.

Pomegranate Juice Powder:

• A clinical trial demonstrated beneficial changes to the gut microflora in 20 healthy adults consuming 1000 mg daily of a pomegranate extract⁷.
• A study using pomegranate juice swilled for a minute in the mouth before swallowing showed antibacterial activity against selected plaque-forming microorganisms⁸.
• A similar study on 30 adults concluded that pomegranate mouth rinse should be explored as a long-term antiplaque rinse with prophylactic benefits⁹.

Serving Type: Nutraceutical Grade Oral Powder.

Available in: 250-gram jar (one scoop = 10 g).

Each 10-gram serve contains as active ingredients:

Lactobacillus plantarum HKL-137 (as LP20) = 10 mg
Larix Arabinogalactans (Larch) = 4,500 mg
Punica granatum (Pomegranate Juice Powder) = 3,000 mg

Excipients: Microcrystalline cellulose, silicon dioxide.

Recommended Daily Dosage:
One or more 10-gram scoops daily in water – or more often for acute states.

Enhanced Daily Dosage:
Up to 8 doses daily may be indicated for acute conditions associated with infection, allergy or inflammation.

Oral Health and Dental Plaque:
Swill in the mouth for 1 minute before swallowing.

Supporting Formulae:
For enhanced clinical effect, MunoGEN may be combined with Integra Nutritionals encapsulated GeneActiv GFD or with other sulforaphane-yielding formulations, GeneActiv GFE, GeneActiv GFP, or combined with powdered EnduraCell or PomGenex.

MunoGEN has no known toxicity.

MunoGEN is free from GMO, wheat (gluten), dairy, lactose, egg, soy, nuts, legumes, yeast, added sugar or other sweeteners or artificial additives.

Please apply children’s dosage rules to all Cell Logic and Integra Nutritionals products.

Store below 30°C in a dry place away from direct light.

1. Int Immunopharmacol. 2009 Jan;9(1):127-33.
2. Regul Toxicol Pharmacol. 2009 Aug;54(3):214-20.
3. Int Immunopharmacol. 2009 Aug;9(9):1122-5.
4. J Nutr. 2006 Dec;136(12):3069 -73.
5. Udani JK. J Am Coll Nutr. 2013 Oct; 32(5): 331–338.
6. Dion et al. Nutrition & Metabolism (2016) 13:28.
7. Li et al. Food Function. 2015:6(8):2487-95.
8. J Herb Pharmacother. 2006;6(2):79-92.
9. Quintessence Int. 2011 Jan;42(1):29-36.