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Broccoli Sprouts in Autism Clinical Trial - New Study

Christine Houghton, Senior Clinician & Chief Scientific Officer, Cell-Logic Pty Ltd

 
Clinical Trial - Autistic Spectrum Disorder (ASD)

Just published (October 13, 2014) in the Proceedings of the National Academy of Sciences is a small clinical trial wherein Broccoli sprout-derived Sulforaphane was used as the active intervention in a placebo-controlled randomised study in 45 males aged 13-27 over 18 weeks.

 

Findings:

Those taking the broccoli sprout supplements showed substantial behaviour improvement, rated by social interaction, abnormal behaviour and verbal communication (34% improved when rated by the Aberrant Behaviour Checklist - ABC and 17% on the Social Responsiveness Scale - SRS).   On discontinuation of the treatment, total scores on all scales rose to pre-treatment levels within 4 weeks.

 

Why choose Sulforaphane?

ASD is known to be underpinned by Oxidative Stress and patients with ASD have limited ability to generate the necessary endogenous protective compounds required to address this Oxidative Stress. Antioxidant vitamins have failed spectacularly in attempting to combat intracellular oxidative stress in numerous clinical trials including hundreds of thousands of participants. Nutrigenomically-active Sulforaphane utilises a different mechanism.

 

Sulforaphane is known to be the most potent activator of the gene expression of a host of antioxidant and detoxification enzymes as well as numerous other protective compounds via Nrf2 signalling.   As such, sulforaphane is the likely intervention in a study of this kind.

 

The Results   

These graphs taken from the published study show the effect of sulforaphane in the ABC and SRS scores. Equally apparent is the loss of positive effect on these scores when sulforaphane is discontinued.

 

How much EnduraCell could provide this effect?

The study used a sulforaphane-yielding broccoli sprout according to the following dosages:

 

Body weight of male participantEquiv. EnduraCell Powder Dose/day (approx.)
Equiv. EnduraCell BioActive Dose/day (approx.)
45 kg
1.8 grams
2 - 3 capsules
90 kg
3.6 grams
3 - 4 capsules
> 90 kg
5.4 grams
5 - 6 capsules

Essentially, prescribe 1 gram of EnduraCell for every 25 kg body weight.

 

NOTE: The scoop supplied with EnduraCell 80 jars of powder holds 1 gram.

 

Source 

http://www.pnas.org/content/early/2014/10/08/1416940111.full.pdf+html?with-ds=yes